Start by patting the tilapia fillets dry with paper towels to remove excess moisture. Season both sides with salt, pepper, paprika, and dried oregano. Set aside.
In a large skillet, melt the butter over medium heat. Once melted, add the minced garlic and sauté for about 1 minute until fragrant, being careful not to let it burn.
Squeeze the lemon juice into the skillet and stir in the lemon zest. Allow it to simmer for about 2 minutes.
Carefully place the seasoned tilapia fillets into the skillet, cooking them for about 3-4 minutes on one side until golden brown.
Flip the fillets gently using a spatula and cook on the other side for an additional 3-4 minutes, or until the fish flakes easily with a fork.
Remove the skillet from heat, and spoon the garlic butter sauce over the tilapia fillets to ensure they are well coated.
Garnish the tilapia with freshly chopped parsley and serve with lemon wedges on the side for extra zest.